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新一季将聚焦2001年美国炭疽攻击事件，该事件是在美国发生的一起从2001年9月18日开始为期数周的生物恐怖袭击。从2001年9月18日开始有人把含有炭疽杆菌的信件寄给数个新闻媒体办公室以及两名民主党参议员。这个事件导致五人死亡，17人被感染。直到2008年最主要的嫌疑人才被公布。金大贤饰演一名擅长微生物学的FBI特工，戈德温饰演一名陆军生物学家，该角色根绝真实人物布鲁斯·艾文斯的经历改编。
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Rachel James is shot through her kitchen window while having breakfast early one morning. She was having an affair with Dr. Julian Storrs, an Oxford professor who is a candidate for Master of Lonsdale College. When her next door neighbor is also killed however, Morse determines that the shooting of James may have been in error. Morse also suspects that he may have been a blackmailer. Both Storrs an his rival for the Masters position, Denis Cornford had secrets that would make them suspects. Morse determines that several others also had things to hide and any one of them could have committed the murders.
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在普林斯顿大学附属医院内，坐镇一位大名鼎鼎的内科医师——格雷戈·豪斯（休·劳瑞 Hugh Laurie 饰），他穿着邋遢随便，手拄拐杖，刚愎自用，锋芒毕露，全然没有人们印象中那类谦和严谨的专业医师的影子。可是在这副令人咋舌的外表之下，却藏着令同行和病患佩服得五体投地的高超医术和丰富学识。豪斯医生治病的手法也独树一帜，他不当面问诊，也绝对不相信病患的道白感受，而完全凭借自己卓越的学识和高超的推理能力解决了诸多疑难杂症。 在神经科医师泰勒·埃瑞克·弗曼（奥尔马·伊普斯 Omar Epps 饰）、免疫学专家阿丽森·卡梅隆（珍妮弗·莫里森 Jennifer Morrison 饰）、心脏与急诊科医师罗伯特·蔡斯（杰西·斯宾塞 Jesse Spencer 饰）的协助下，豪斯团队绽放出耀眼夺目的光芒，也创造了一个又一个医学奇迹……
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在这部未来惊悚片，世界成为一片冰冻的荒芜之地。残存的人类居住在一列巨型列车上，永无止尽地绕行全球。
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Morse finds himself the subject of a murder investigation when his friend, Beryl Newsome, is murdered at a rehearsal of the Magic Flute and he foolishly touches the murder weapon. Morse is suspended and DCI Bottomley, with DS Lewis assisting him, is put in charge of the case. Morse feels that he was set-up and looks to his past to see who, among the many criminals he arrested, might now be setting about seeking revenge. When someone scratches masonic symbols all over his car and he is reported for erratic driving, Morse wonders if Masons may somehow be involved. When a large number of his personal items are found in Beryl's apartment, Morse is placed under arrest.