根据《惊声尖叫》系列电影改编，残忍谋杀案后引起的网络讨论唤起人们对过去杀人狂魔的记忆，引起某些人的好奇，也启发了新的杀人犯。两个老朋友和一群年轻人为此重新联系起来，他们互相成为恋人、敌人、冷血杀手嫌疑人、目标和幸存者。

Recognizing the destructive power of its captive giant Ape, the military makes its own battle-ready A.I., Mecha Ape but its first practical test goes horribly wrong, leaving the military no choice but to release the imprisoned giant ape to stop the colossal robot before it destroys downtown Chicago.