Many, many years ago, the beautiful Medusa was severely punished by Athena, the virgin goddess, for the loss of her purity. Today, Mariana belongs to a world where she must do her utmost to keep up the appearance of a perfect woman. In order not to fall into temptation, she tries hard to control everything and everyone around her. However, the day will come when the urge to scream will be stronger than it ever has been.

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阿尔玛穆拉是南美神话中的骡妖，据说是由乱搞不伦关系的无德女人所变，她被上帝诅咒成为一只套着沉重铁链的骡子，在暴风雨夜晚的安第斯山脉徘徊，发现它的人都会被踢死。而所有它经过的地方，发生禁恋的人也会变成阿尔玛穆拉。纤细男孩尼诺由于受到恐同袭击，不得不和父母搬到乡下。当地森林据说常发生诡异事件，也有小男孩无故失踪。叛逆和好奇心让尼诺对传说产生浓厚兴趣，他期盼着能与骡妖相遇……