Maca (María Valverde), 30 years old and clumsy by nature, makes the most of life and strives to be happy. Maca's talent is wasted working as an assistant for an oppressive and terrifying fashion influencer and she spends her time with guys with whom she never manages to establish an emotional bond. Together with Jimena (Elísabet Casanovas) and Adriana (Susana Abaitúa), her two unique and lovable friends who are always ready to do whatever it takes to make their problems not seem so bad, Maca has managed to make Madrid a city where everything is possible. Everything seems to be going well until he-who-must-not-be-named comes back into her life. Leo (Alex González), the love and biggest mistake of her life, the man who tore her heart apart, obliterated her self-esteem and her faith in men, comes back into her life to turn everything upside down. Maca has tried to forget him, but now she has to accept that he has returned and face the emotions she has locked away to deal with the unforgettable memory of what could have been and never was. Old wounds are reopened and Maca will have to be brave and confront her conflicts, fears and insecurities in order to finally take control of her life.

三位理科宅男，大學時期就是換帖好友，畢業後卻面臨金融風暴而失業，只好隨便找份工作餬口。某天，成為化學系教授的貝德羅（大衛貝爾塔格飾演），打造出一款增強注意力的維生素，卻因為研究經費不足慘遭校方解雇。走投無路之下，貝德羅竟揪兩位好友一起吞了這款維生素，更意外發現這款藥丸不但沒有副作用，還會讓人情緒高亢！於是，他們決定不當乖乖牌，開始走歪路開啟製毒事業，想靠賣藥日進斗金，天天開趴嗨到翻。不過他們萬萬沒想到，原本平凡的生活，就這樣陷入充滿危險的夜世界…。